:orphan: 





.. _biolag_both_fit:



Bioavailability and Lag
#######################

[Generated automatically as a Fitting summary]

Model Description
*****************


:Name: biolag_both

:Title: Bioavailability and Lag

:Author: PoPy for PK/PD

:Abstract: 

| One compartment model with bioavailability and lag parameters.

:Keywords: identifiability; bioavailability; lag; iv_one_cmp_cl

:Input Script: :download:`biolag_both_fit.pyml <biolag_both_fit.pyml>`

:Diagram: 


.. thumbnail:: biolag_both_fit.pyml_output/compartment_diagram.svg
    :width: 200px


Comparison
**********



Compare Main f[X]
=================


===============  ================  ==============  ============  =============
Variable Name      Starting Value    Fitted Value    Abs Change    Prop Change
===============  ================  ==============  ============  =============
f[CL]                      1.0000          2.0897        1.0897         1.0897
f[V]                      15.0000         11.2811        3.7189         0.2479
f[BIO]                     0.8000          0.8015        0.0015         0.0018
f[LAG]                     1.0000          0.0212        0.9788         0.9788
===============  ================  ==============  ============  =============

Compare Noise f[X]
==================


===============  ================  ==============  ============  =============
Variable Name      Starting Value    Fitted Value    Abs Change    Prop Change
===============  ================  ==============  ============  =============
f[ANOISE_STD]              5.0000          0.9210        4.0790         0.8158
===============  ================  ==============  ============  =============

Compare Variance f[X]
=====================




Population simulated (sim) plots
================================


.. list-table:: 
    :width: 90%

    * - .. thumbnail:: images/fit_sim_grph_outputs/indOBS_vs_TIME/000001.svg
            :width: 200px
      - indOBS_vs_TIME

Outputs
*******



Final objective value
=====================

.. code-block:: pyml

    83.5562


which required 1.11 iterations and took 10.98 seconds

Fitted f[X] values (after fitting)
==================================


.. code-block:: pyml

    f[CL] = 2.0897
    f[V] = 11.2811
    f[ANOISE_STD] = 0.9210
    f[BIO] = 0.8015
    f[LAG] = 0.0212



Fitted parameter .csv files
===========================


:Fixed Effects: :download:`fx_params.csv (fit) <biolag_both_fit.pyml_output/solN/fx_params.csv>`

:Random Effects: :download:`rx_params.csv (fit) <biolag_both_fit.pyml_output/solN/rx_params.csv>`

:Model params: :download:`mx_params.csv (fit) <biolag_both_fit.pyml_output/solN/mx_params.csv>`

:State values: :download:`sx_params.csv (fit) <biolag_both_fit.pyml_output/solN/sx_params.csv>`

:Predictions: :download:`px_params.csv (fit) <biolag_both_fit.pyml_output/solN/px_params.csv>`

:Likelihoods: :download:`lx_params.csv (fit) <biolag_both_fit.pyml_output/solN/lx_params.csv>`



Inputs
******


:Input Data: :download:`cx_obs_params.csv <cx_obs_params.csv>`


Starting f[X] values (before fitting)
=====================================


.. code-block:: pyml

    f[CL] = 1.0000
    f[V] = 15.0000
    f[ANOISE_STD] = 5.0000
    f[BIO] = 0.8000
    f[LAG] = 1.0000

