:orphan: 





.. _emax_biomarker_gen:



emax_marker_model
#################

[Generated automatically as a Generation summary]

Model Description
*****************


:Name: emax_biomarker

:Title: emax_marker_model

:Author: PoPy for PK/PD

:Abstract: 

| An emax Model, based on the concentration of drug in the central compartment.
| The amount in the central compartment is determined by CL/V, which has been estimated for each individual.
| The concentration in the central compartment influences the rate of removal of a biomarker (KOUT).

:Keywords: PD; Pharmacodynamics; one compartment model; KIN; KOUT; emax; biomarker

:Input Script: :download:`emax_biomarker_gen.pyml <emax_biomarker_gen.pyml>`

:Diagram: 


.. thumbnail:: emax_biomarker_gen.pyml_output/compartment_diagram.svg
    :width: 200px


Outputs
*******



Population simulated (sim) plots
================================


.. list-table:: 
    :width: 90%

    * - .. thumbnail:: images/gen_sim_grph_outputs/indOBS_vs_TIME/000001.svg
            :width: 200px
      - indOBS_vs_TIME

Generated parameter .csv files
==============================


:Fixed Effects: :download:`fx_params.csv (gen) <emax_biomarker_gen.pyml_output/fx_params.csv>`

:Random Effects: :download:`rx_params.csv (gen) <emax_biomarker_gen.pyml_output/rx_params.csv>`

:Model params: :download:`mx_params.csv (gen) <emax_biomarker_gen.pyml_output/mx_params.csv>`

:State values: :download:`sx_params.csv (gen) <emax_biomarker_gen.pyml_output/sx_params.csv>`

:Predictions: :download:`px_params.csv (gen) <emax_biomarker_gen.pyml_output/px_params.csv>`


:Observations: :download:`synthetic_data.csv (gen) <synthetic_data.csv>`


Inputs
******



True f[X] values (for simulation)
=================================


.. code-block:: pyml

    f[KIN] = 10.0000
    f[KOUT] = 0.0500
    f[EMAX] = 80.0000
    f[E50] = 30.0000
    f[ANOISE] = 1.0000

