Flip Flop tutorial with inaccurate starting values

[Generated automatically as a Generation summary]

Model Description

Name:

flip_flop_bad

Title:

Flip Flop tutorial with inaccurate starting values

Author:

PoPy for PK/PD

Abstract:

One compartment model with a depot leading into a central compartment.

Here initial values of KE, KA, V are close to the flipped values, so we get a bad fit in the false minima.

Keywords:

flip flop; dep_one_cmp_k; one compartment model; poor start values

Input Script:

flip_flop_bad_gen.pyml

Diagram:

Outputs

Population simulated (sim) plots

indOBS_vs_TIME

Generated parameter .csv files

Fixed Effects:

fx_params.csv (gen)

Random Effects:

rx_params.csv (gen)

Model params:

mx_params.csv (gen)

State values:

sx_params.csv (gen)

Predictions:

px_params.csv (gen)

Observations:

synthetic_data.csv (gen)

Inputs

True f[X] values (for simulation)

f[KA] = 0.1500
f[KE] = 0.3000
f[ANOISE_STD] = 1.0000