binary_emax_PD_model

[Generated automatically as a Generation summary]

Model Description

Name:

emax_binary

Title:

binary_emax_PD_model

Author:

PoPy for PK/PD

Abstract:

An emax PK/PD Model, based on the amount of drug in the body.

The two compartment PK model with previously estimated values of K, K21 and K12 for each individual.

The amount in the central compartment influences the effect compartment along with EMAX (the maximum effect) and EC50 (the amount at which the effect is half the maximum)

Keywords:

PD; Pharmacodynamics; two compartment model; emax; EC50; binary response

Input Script:

emax_binary_gen.pyml

Diagram:

Outputs

Population simulated (sim) plots

indOBS_vs_TIME

Generated parameter .csv files

Fixed Effects:

fx_params.csv (gen)

Random Effects:

rx_params.csv (gen)

Model params:

mx_params.csv (gen)

State values:

sx_params.csv (gen)

Predictions:

px_params.csv (gen)

Observations:

synthetic_data.csv (gen)

Inputs

True f[X] values (for simulation)

f[EMAX] = 80.0000
f[E50] = 20.0000
f[ANOISE] = 1.0000