emax_marker_model

[Generated automatically as a Generation summary]

Model Description

Name:: emax_biomarker
Title:: emax_marker_model
Author:: PoPy for PK/PD
Abstract:

An emax Model, based on the concentration of drug in the central compartment.
The amount in the central compartment is determined by CL/V, which has been estimated for each individual.
The concentration in the central compartment influences the rate of removal of a biomarker (KOUT).

Keywords:: PD; Pharmacodynamics; one compartment model; KIN; KOUT; emax; biomarker
Input Script:: emax_biomarker_gen.pyml
Diagram:

Outputs

Population simulated (sim) plots

indOBS_vs_TIME

Generated parameter .csv files

Fixed Effects:: fx_params.csv (gen)
Random Effects:: rx_params.csv (gen)
Model params:: mx_params.csv (gen)
State values:: sx_params.csv (gen)
Predictions:: px_params.csv (gen)
Observations:: synthetic_data.csv (gen)

Inputs

True f[X] values (for simulation)

f[KIN] = 10.0000
f[KOUT] = 0.0500
f[EMAX] = 80.0000
f[E50] = 30.0000
f[ANOISE] = 1.0000