Direct Effect Emax PD Model
[Generated automatically as a Tutorial summary]
Model Description
- Name:
emax_nondiff
- Title:
Direct Effect Emax PD Model
- Author:
PoPy for PK/PD
- Abstract:
A direct effect emax PK/PD Model, based on the concentration of drug in the body.
The one compartment PK model uses previously estimated values of CL and V for each individual
The concentration in the central compartment influences the effect.
The effect is not a compartment and so does not increase over time. It is dependent on the baseline effect, the concentration in the central compartment, the maximum effect (emax) and concentration at which the effect is half the maximum (EC50).
- Keywords:
PD; Pharmacodynamics; one compartment model; emax; EC50; baseline effect
- Input Script:
- Diagram:
Comparison
True objective value
-52.6006
Final fitted objective value
-54.8713
Compare Main f[X]
No Main f[X] values to compare.
Compare Noise f[X]
Name |
Initial |
Fitted |
True |
Abs. Error |
Prop. Error |
|---|---|---|---|---|---|
f[EMAX] |
80 |
523 |
100 |
4.23e+02 |
422.67% |
f[E50] |
50 |
323 |
60 |
2.63e+02 |
438.07% |
f[EBASE] |
5 |
10… |
10 |
1.49e-02 |
0.15% |
f[ANOISE] |
2 |
0.46 |
0.5 |
3.98e-02 |
7.95% |
Compare Variance f[X]
No Variance f[X] values to compare.
Outputs
Fitted f[X] values (after fitting)
f[EMAX] = 522.6699
f[E50] = 322.8391
f[EBASE] = 10.0149
f[ANOISE] = 0.4602
Generated data .csv file
- Synthetic Data:
Gen and Fit Summaries
Gen: Direct Effect Emax PD Model (gen)
Fit: Direct Effect Emax PD Model (fit)
Inputs
True f[X] values (for simulation)
f[EMAX] = 100.0000
f[E50] = 60.0000
f[EBASE] = 10.0000
f[ANOISE] = 0.5000
Starting f[X] values (before fitting)
f[EMAX] = 80.0000
f[E50] = 50.0000
f[EBASE] = 5.0000
f[ANOISE] = 2.0000