Emax PD Model

[Generated automatically as a Generation summary]

Model Description

Name:: emax_simple
Title:: Emax PD Model
Author:: PoPy for PK/PD
Abstract:

A simple emax PKPD Model, based on the amount of drug in the body.
The two compartment PK model uses previously estimated values of K, K21 and K12 for each individual
The amount in the central compartment influences the effect compartment along with EMAX (the maximum effect) and EC50 (the amount at which the effect is half the maximum)

Keywords:: PD; Pharmacodynamics; two compartment model; emax; EC50
Input Script:: emax_simple_gen.pyml
Diagram:

Outputs

Population simulated (sim) plots

indOBS_vs_TIME

Generated parameter .csv files

Fixed Effects:: fx_params.csv (gen)
Random Effects:: rx_params.csv (gen)
Model params:: mx_params.csv (gen)
State values:: sx_params.csv (gen)
Predictions:: px_params.csv (gen)
Observations:: synthetic_data.csv (gen)

Inputs

True f[X] values (for simulation)

f[EMAX] = 80.0000
f[E50] = 20.0000
f[ANOISE] = 1.0000