Nonmem ADVAN3 TRANS6 example

[Generated automatically as a Generation summary]

Model Description

Name:: advan3trans6_pop
Title:: Nonmem ADVAN3 TRANS6 example
Author:: PoPy for PK/PD
Abstract:

ADVAN 3 TRANS6 problem. Central compartment with a peripheral compartment.
trans 6 parameters:-
* K21 is the rate from the peripheral to the central compartment
* ALPHA
* BETA
map to advan3 parameters:-
* K21 = K21
* K12 = ALPHA+BETA-K21-K
* KE = APLHA*BETA/K21
ALPHA<K21<BETA. This must be true for model to work.

Keywords:: advan3; trans6; two compartment model
Input Script:: advan3trans6_pop_gen.pyml
Diagram:

Outputs

Individual simulated (sim) plots

Alternatively see All simulated_sim graph plots

Population simulated (sim) plots

(No population graphs were requested.)

Generated parameter .csv files

Fixed Effects:: fx_params.csv (gen)
Random Effects:: rx_params.csv (gen)
Model params:: mx_params.csv (gen)
State values:: sx_params.csv (gen)
Predictions:: px_params.csv (gen)
Observations:: synthetic_data.csv (gen)

Inputs

True f[X] values (for simulation)

f[ALPHA] = 0.2000
f[DIFFALPHAK21] = 0.3000
f[DIFFK21BETA] = 0.3000
f[PNOISE] = 0.0100
f[ANOISE] = 0.0100
f[ALPHA_isv,DIFFALPHAK21_isv,DIFFK21BETA_isv] = [
    [ 0.1000, 0.0000, 0.0000 ],
    [ 0.0000, 0.0500, 0.0000 ],
    [ 0.0000, 0.0000, 0.0200 ],
]