Repeated Dosing

There need not be only one dose administered to the subject for a given experiment – several doses may be given, for example to maintain drug concentration at a steady state over a period of time. PoPy handles this by allowing multiple dose lines in the data file and superimposing the resulting curves, see table_repeated_dosing.

Repeated dosing, administered to a one compartment model with first order elimination

Repeated Bolus Dosing	Repeated Infusion Dosing
Repeated Gamma Dosing	Repeated Weibull Dosing

Note

See Repeated Bolus Dose with first order elimination., Repeated Infusion Rate Dose with first order elimination., Repeated Gamma Dose with first order elimination. and Repeated Weibull Dose with first order elimination. for the tutorial scripts used to generate results in this section.

Note PoPy can superimpose consecutive complex Dosing Functions (e.g. Weibull and Gamma functions) that can cause numerical instability in other PK/PD packages.