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One Compartment Model with Absorption estimating KA, CL and V

[Generated automatically as a Fitting summary]

Inputs

Description

Name:dep_one_cmp_ka_v_cl_stderr
Title:One Compartment Model with Absorption estimating KA, CL and V
Author:Wright Dose Ltd
Abstract:
One Compartment Model with Absorption compartment with rate (KA).
Elimination rate parametrised by clearance (CL)
and volume of distribution (V).
Model specification uses incremental flows
Keywords:dep_one_cmp_cl; one compartment model
Input Script:dep_one_cmp_ka_v_cl_stderr_fit.pyml
Input Data:synthetic_data.csv
Diagram:

Initial fixed effect estimates

f[KA] = 0.3
f[V] = 20
f[CL] = 3

Outputs

Final objective value

-44.7677718823

which required 5 iterations and took 0.14 seconds

Final fitted fixed effects

f[KA] = 0.27392
f[V] = 18.003
f[CL] = 3.2389

Fitted parameter .csv files

Fixed Effects:fx_params.csv (fit)
Random Effects:rx_params.csv (fit)
Model params:mx_params.csv (fit)
State values:sx_params.csv (fit)
Predictions:px_params.csv (fit)

Plots

Dense sim plots

Alternatively see All dense_sim graph plots

Comparison

Compare Main f[X]

Variable Name Fitted Value Starting Value Prop Change Abs Change
f[KA] 0.273923 0.3 0.0869238 0.0260771
f[V] 18.0027 20 0.099866 1.99732
f[CL] 3.2389 3 0.0796349 0.238905

Compare Noise f[X]

Compare Variance f[X]

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