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Full matrix generation diagonal matrix fit

[Generated automatically as a Fitting summary]

Inputs

Description

Name:gen_full_fit_diag
Title:Full matrix generation diagonal matrix fit
Author:Wright Dose Ltd
Abstract:
One compartment model with absorption compartment and CL/V parametrisation.
This script uses a full covariance matrix to generate the data, but a diagonal matrix to fit.
Keywords:dep_one_cmp_cl; one compartment model; diagonal matrix; full matrix
Input Script:gen_full_fit_diag_fit.pyml
Input Data:synthetic_data.csv
Diagram:

Initial fixed effect estimates

f[KA] = 0.3
f[CL] = 3
f[V] = 20
f[PNOISE_STD] = 0.1
f[ANOISE_STD] = 0.05
f[CL_isv,V_isv] = [
    [ 0.01, 0 ],
    [ 0, 0.01 ]
]

Outputs

Final objective value

-2187.54430299

which required 9 iterations and took 84.20 seconds

Final fitted fixed effects

f[KA] = 0.3
f[CL] = 3
f[V] = 20
f[PNOISE_STD] = 0.1
f[ANOISE_STD] = 0.05
f[CL_isv,V_isv] = [
    [ 0.11772, 0 ],
    [ 0, 0.12139 ]
]

Fitted parameter .csv files

Fixed Effects:fx_params.csv (fit)
Random Effects:rx_params.csv (fit)
Model params:mx_params.csv (fit)
State values:sx_params.csv (fit)
Predictions:px_params.csv (fit)

Plots

Dense sim plots

Alternatively see All dense_sim graph plots

Comparison

Compare Main f[X]

Compare Noise f[X]

Compare Variance f[X]

Variable Name Fitted Value Starting Value Prop Change Abs Change
f[CL_isv] 0.117716 0.01 10.7716 0.107716
f[CL_isv;V_isv] 0 0   0
f[V_isv;CL_isv] 0 0   0
f[V_isv] 0.121386 0.01 11.1386 0.111386
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