- Language: en
Sine circadian model¶
[Generated automatically as a Tutorial summary]
Inputs¶
Description¶
Name: | circ_sin |
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Title: | Sine circadian model |
Author: | Wright Dose Ltd |
Abstract: |
A PD Model based on the amount of drug in the body.
The PD model uses a sine function which simulates a circadian rhythm for the generation of a biomarker.
The amount in the central compartment is determined by CL and V, PK patameters , which have been previosly estimated for each individual.
The amount in the central compartment influences the rate of production of a biomarker.
Keywords: | PD; Pharmacodynamics; sine function; Circadian rhythm |
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Input Script: | circ_sin_tut.pyml |
Diagram: |
True f[X] values¶
f[AMP] = 2.0000
f[INT] = 8.0000
f[KOUT] = 0.0500
f[ANOISE] = 3.0000
Starting f[X] values¶
f[AMP] = 3.0000
f[INT] = 16.0000
f[KOUT] = 0.1000
f[ANOISE] = 5.0000
Outputs¶
Generating and Fitting Summaries¶
- Gen: Sine circadian model (gen)
- Fit: Sine circadian model (fit)
Fitted f[X] values¶
f[AMP] = 1.9936
f[INT] = 19.9038
f[KOUT] = 0.0497
f[ANOISE] = 10.0000
Plots¶
Comparison¶
True objective value¶
815.0562
Final fitted objective value¶
1175.2009
Compare Main f[X]¶
Name | Initial | Fitted | True | Prop. Error | Abs. Error |
---|---|---|---|---|---|
f[AMP] | 3 | 1.99 | 2 | 0.32% | 6.36e-03 |
f[INT] | 16 | 19.9 | 8 | 148.80% | 1.19e+01 |
f[KOUT] | 0.1 | 0.0497 | 0.05 | 0.58% | 2.89e-04 |
Compare Noise f[X]¶
Name | Initial | Fitted | True | Prop. Error | Abs. Error |
---|---|---|---|---|---|
f[ANOISE] | 5 | 10 | 3 | 233.33% | 7.00e+00 |
Compare Variance f[X]¶
No Variance f[X] values to compare.