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One Compartment Model with Absorption and Inter-subject Variance f[CL_isv]=0.2

[Generated automatically as a Fitting summary]

Inputs

Description

Name:dep_one_cmp_cl_isv
Title:One Compartment Model with Absorption and Inter-subject Variance f[CL_isv]=0.2
Author:Wright Dose Ltd
Abstract:
Population one Compartment Model with Absorption and Inter-subject Variance
Keywords:one compartment model; dep_one_cmp_cl
Input Script:dep_one_cmp_cl_isv_fit.pyml
Input Data:synthetic_data.csv
Diagram:

Initial fixed effect estimates

f[KA] = 0.5000
f[CL] = 1.0000
f[V] = 15.0000
f[PNOISE_STD] = 0.2000
f[ANOISE_STD] = 0.2000
f[CL_isv] = 0.0100

Outputs

Final objective value

-307.4576

which required 33 iterations and took 66.63 seconds

Final fitted fixed effects

f[KA] = 1.0000
f[CL] = 2.2896
f[V] = 19.5314
f[PNOISE_STD] = 0.2402
f[ANOISE_STD] = 0.0368
f[CL_isv] = 0.1252

Fitted parameter .csv files

Fixed Effects:fx_params.csv (fit)
Random Effects:rx_params.csv (fit)
Model params:mx_params.csv (fit)
State values:sx_params.csv (fit)
Predictions:px_params.csv (fit)

Plots

Dense sim plots

Alternatively see All dense_sim graph plots

Comparison

Compare Main f[X]

Variable Name Fitted Value Starting Value Prop Change Abs Change
f[KA] 1.0000 0.5000 1.0000 0.5000
f[CL] 2.2896 1.0000 1.2896 1.2896
f[V] 19.5314 15.0000 0.3021 4.5314

Compare Noise f[X]

Variable Name Fitted Value Starting Value Prop Change Abs Change
f[PNOISE_STD] 0.2402 0.2000 0.2010 0.0402
f[ANOISE_STD] 0.0368 0.2000 0.8162 0.1632

Compare Variance f[X]

Variable Name Fitted Value Starting Value Prop Change Abs Change
f[CL_isv] 0.1252 0.0100 11.5209 0.1152
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