- Language: en
Sine circadian model¶
[Generated automatically as a Generation summary]
Inputs¶
Description¶
| Name: | circ_sin |
|---|---|
| Title: | Sine circadian model |
| Author: | Wright Dose Ltd |
| Abstract: |
A PD Model based on the amount of drug in the body.
The PD model uses a sine function which simulates a circadian rhythm for the generation of a biomarker.
The amount in the central compartment is determined by CL and V, PK patameters , which have been previosly estimated for each individual.
The amount in the central compartment influences the rate of production of a biomarker.
| Keywords: | PD; Pharmacodynamics; sine function; Circadian rhythm |
|---|---|
| Input Script: | circ_sin_gen.pyml |
| Diagram: |
True f[X] values¶
f[AMP] = 2.0000
f[INT] = 8.0000
f[KOUT] = 0.0500
f[ANOISE] = 3.0000
Outputs¶
Generated parameter .csv files¶
| Fixed Effects: | fx_params.csv (gen) |
|---|---|
| Random Effects: | rx_params.csv (gen) |
| Model params: | mx_params.csv (gen) |
| State values: | sx_params.csv (gen) |
| Predictions: | px_params.csv (gen) |
| Synthetic Data: | synthetic_data.csv (gen) |
