Sine circadian model¶
[Generated automatically as a Generation summary]
Model Description¶
| Name: | circ_sin |
|---|---|
| Title: | Sine circadian model |
| Author: | PoPy for PK/PD |
| Abstract: |
A PD Model based on the amount of drug in the body.
The PD model uses a sine function which simulates a circadian rhythm for the generation of a biomarker.
The amount in the central compartment is determined by CL and V, PK patameters , which have been previosly estimated for each individual.
The amount in the central compartment influences the rate of production of a biomarker.
| Keywords: | PD; Pharmacodynamics; sine function; Circadian rhythm |
|---|---|
| Input Script: | circ_sin_gen.pyml |
| Diagram: |
Outputs¶
Population simulated (sim) plots¶
|
indOBS_vs_TIME |
Generated parameter .csv files¶
| Fixed Effects: | fx_params.csv (gen) |
|---|---|
| Random Effects: | rx_params.csv (gen) |
| Model params: | mx_params.csv (gen) |
| State values: | sx_params.csv (gen) |
| Predictions: | px_params.csv (gen) |
| Observations: | synthetic_data.csv (gen) |