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Sine circadian model

[Generated automatically as a Generation summary]

Model Description

Name:circ_sin
Title:Sine circadian model
Author:PoPy for PK/PD
Abstract:
A PD Model based on the amount of drug in the body.
The PD model uses a sine function which simulates a circadian rhythm for the generation of a biomarker.
The amount in the central compartment is determined by CL and V, PK patameters , which have been previosly estimated for each individual.
The amount in the central compartment influences the rate of production of a biomarker.
Keywords:PD; Pharmacodynamics; sine function; Circadian rhythm
Input Script:circ_sin_gen.pyml
Diagram:

Outputs

Population simulated (sim) plots

indOBS_vs_TIME

Generated parameter .csv files

Fixed Effects:fx_params.csv (gen)
Random Effects:rx_params.csv (gen)
Model params:mx_params.csv (gen)
State values:sx_params.csv (gen)
Predictions:px_params.csv (gen)
Observations:synthetic_data.csv (gen)

Inputs

True f[X] values (for simulation)

f[AMP] = 2.0000
f[INT] = 8.0000
f[KOUT] = 0.0500
f[ANOISE] = 3.0000
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