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Nonmem Advan1,2,3,4,11,12 to PoPy analytic compartment models

Table 59 shows how to convert each Nonmem inbuilt ADVAN analytic functions to PoPy equivalents.

See ADVAN 1,2,3,4,11,12 Example for info on Nonmem $SUBROUTINES section.

Note to use the analytic compartment models in PoPy you should always set ODE_SOLVER as follows:-

ODE_SOLVER: {ANALYTIC:{}}

For more information on PoPy analytic functions see Analytic Compartment Functions.

Table 59 Nonmem to PoPy Analytic ODEs
Nonmem ADVAN Parameters PoPy CMP Parameters
ADVAN1 K @iv_one_cmp_k KE
ADVAN1 TRANS2 CL/V @iv_one_cmp_cl CL/V
ADVAN2 KA/K @dep_one_cmp_k KA/KE
ADVAN2 TRANS2 KA/CL/V @dep_one_cmp_cl KA/CL/V
ADVAN3 K/K12/K21 @iv_two_cmp_k KE/K12/K21
ADVAN3 TRANS4 CL/V1/Q/V2 @iv_two_cmp_cl CL/V1/Q/V2
ADVAN4 KA/K/K23/K32 @dep_two_cmp_k KA/KE/K12/K21
ADVAN4 TRANS4 KA/CL/V1/Q/V2 @dep_two_cmp_cl KA/CL/V1/Q/V2
ADVAN11 K/K12/K21/K13/K31 @iv_three_cmp_k KE/K12/K21/K13/K31
ADVAN11 TRANS4 CL/V1/Q2/V2/Q3/V3 @iv_three_cmp_cl CL/V1/Q2/V2/Q3/V3
ADVAN12 KA/K/K23/K32/K24/K42 @dep_three_cmp_k KA/KE/K12/K21/K13/K31
ADVAN12 TRANS4 KA/CL/V2/Q3/V3/Q4/V4 @dep_three_cmp_cl KA/CL/V1/Q2/V2/Q3/V3

ADVAN1

In Nonmem:-

$SUBROUTINES  ADVAN1

With following parameters defined in the Nonmem $PK section:-

  • K = elimination rate

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[CEN] = @iv_one_cmp_k{dose: @bolus{amt:c[AMT]}, KE: m[KE]}

The Nonmem parameters are mapped to PoPy as follows:-

  • K -> KE

See @iv_one_cmp_k.

ADVAN1 TRANS2

In Nonmem:-

$SUBROUTINES  ADVAN1 TRAN2

With following parameters defined in the Nonmem $PK section:-

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[CEN] = @iv_one_cmp_cl{dose: @bolus{amt:c[AMT]}, CL: m[CL], V: m[V]}

The Nonmem parameters are mapped to PoPy as follows:-

  • CL -> CL
  • V -> V

See @iv_one_cmp_cl.

ADVAN2

In Nonmem:-

$SUBROUTINES  ADVAN2

With following parameters defined in the Nonmem $PK section:-

  • KA = absorption rate
  • K = elimination rate

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[DEP,CEN] = @dep_one_cmp_k{dose: @bolus{amt:c[AMT]}, KA: m[KA], KE: m[KE]}

The Nonmem parameters are mapped to PoPy as follows:-

  • KA -> KA
  • K -> KE

See @dep_one_cmp_k.

ADVAN2 TRANS2

In Nonmem:-

$SUBROUTINES  ADVAN2 TRAN2

With following parameters defined in the Nonmem $PK section:-

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[DEP,CEN] = @dep_one_cmp_cl{
        dose: @bolus{amt:c[AMT]},
        KA: m[KA], CL: m[CL], V: m[V]
    }

The Nonmem parameters are mapped to PoPy as follows:-

  • KA -> KA
  • CL -> CL
  • V -> V

See @dep_one_cmp_cl.

ADVAN3

In Nonmem:-

$SUBROUTINES  ADVAN3

With following parameters defined in the Nonmem $PK section:-

  • K = elimination rate from central compartment
  • K12 = elimination rate from central to peripheral compartment
  • K21 = elimination rate from peripheral to central compartment

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[CEN,PERI] = @iv_two_cmp_k{
        dose: @bolus{amt:c[AMT]},
        KE: m[KE], K12: m[K12], K21: m[K21]}

The Nonmem parameters are mapped to PoPy as follows:-

  • K -> KE
  • K12 -> K12
  • K21 -> K21

See @iv_two_cmp_k.

ADVAN3 TRANS4

In Nonmem:-

$SUBROUTINES  ADVAN3 TRANS4

With following parameters defined in the Nonmem $PK section:-

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[CEN,PERI] = @iv_two_cmp_cl{
        dose: @bolus{amt:c[AMT]},
        CL: m[CL], V1: m[V1], Q: m[Q], V2: m[V2]}

The Nonmem parameters are mapped to PoPy as follows:-

  • CL -> CL
  • V1 -> V1
  • Q -> Q
  • V2 -> V2

See @iv_two_cmp_cl.

ADVAN4

In Nonmem:-

$SUBROUTINES  ADVAN4

With following parameters defined in the Nonmem $PK section:-

  • KA = absorption rate from depot to central compartment
  • K = elimination rate from central compartment
  • K23 = elimination rate from central to peripheral compartment
  • K32 = elimination rate from peripheral to central compartment

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[DEP,CEN,PERI] = @dep_two_cmp_k{
        dose: @bolus{amt:c[AMT]},
        KA: m[KA], KE: m[KE], K12: m[K12], K21: m[K21]}

The Nonmem parameters are mapped to PoPy as follows:-

  • KA -> KA
  • K -> KE
  • K23 -> K12
  • K32 -> K21

Note PoPy uses consistent parameter names between @iv_two_cmp_k (advan3) and @dep_two_cmp_k (advan4), whereas Nonmem renumbers the parameters.

See @dep_two_cmp_k.

ADVAN4 TRANS4

In Nonmem:-

$SUBROUTINES  ADVAN4 TRANS4

With following parameters defined in the Nonmem $PK section:-

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[DEP,CEN,PERI] = @dep_two_cmp_cl{
        dose: @bolus{amt:c[AMT]},
        KA: m[KA], CL: m[CL], V1: m[V1],
        Q: m[Q], V2: m[V2]}

The Nonmem parameters are mapped to PoPy as follows:-

  • KA -> KA
  • CL -> CL
  • V2 -> V1
  • Q -> Q
  • V3 -> V2

Note PoPy uses consistent parameter names between @iv_two_cmp_cl (advan3 trans 4) and @dep_two_cmp_cl (advan4 trans4), whereas Nonmem renumbers the parameters.

See @dep_two_cmp_cl.

ADVAN11

In Nonmem:-

$SUBROUTINES  ADVAN11

With following parameters defined in the Nonmem $PK section:-

  • K = elimination rate from central compartment
  • K12 = elimination rate from central to first peripheral compartment
  • K21 = elimination rate from first peripheral to central compartment
  • K13 = elimination rate from central to second peripheral compartment
  • K31 = elimination rate from second peripheral to central compartment

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[CEN,PERI1,PERI2] = @iv_three_cmp_k{
        dose: @bolus{amt:c[AMT]},
        KE: m[KE], K12: m[K12], K21: m[K21],
        K13: m[K13], K31: m[K31]}

The Nonmem parameters are mapped to PoPy as follows:-

  • K -> KE
  • K12 -> K12
  • K21 -> K21
  • K13 -> K13
  • K31 -> K31

See @iv_three_cmp_k.

ADVAN11 TRANS4

In Nonmem:-

$SUBROUTINES  ADVAN11 TRANS4

With following parameters defined in the Nonmem $PK section:-

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[CEN,PERI1,PERI2] = @iv_three_cmp_cl{
        dose: @bolus{amt:c[AMT]},
        CL: m[CL], V1: m[V1], Q2: m[Q2],
        V2: m[V2], Q3: m[Q3], V3: m[V3]}

The Nonmem parameters are mapped to PoPy as follows:-

  • CL -> CL
  • V1 -> V1
  • Q2 -> Q2
  • V2 -> V2
  • Q3 -> Q3
  • V3 -> V3

See @iv_three_cmp_cl.

ADVAN12

In Nonmem:-

$SUBROUTINES  ADVAN12

With following parameters defined in the Nonmem $PK section:-

  • KA = absorption rate from depot to central compartment
  • K = elimination rate from central compartment
  • K23 = elimination rate from central to first peripheral compartment
  • K32 = elimination rate from first peripheral to central compartment
  • K24 = elimination rate from central to second peripheral compartment
  • K42 = elimination rate from second peripheral to central compartment

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[DEP,CEN,PERI1,PERI2] = @dep_three_cmp_k{
        dose: @bolus{amt:c[AMT]},
        KA: m[KA], KE: m[KE],
        K12: m[K12], K21: m[K21],
        K13: m[K13], K31: m[K31]}

The Nonmem parameters are mapped to PoPy as follows:-

  • KA -> KA
  • K -> KE
  • K23 -> K12
  • K32 -> K21
  • K24 -> K13
  • K42 -> K31

Note PoPy uses consistent parameter names between @iv_three_cmp_k (advan11) and @dep_three_cmp_k (advan12), whereas Nonmem renumbers the parameters.

See @dep_three_cmp_k.

ADVAN12 TRANS4

In Nonmem:-

$SUBROUTINES  ADVAN12 TRANS4

With following parameters defined in the Nonmem $PK section:-

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[DEP,CEN,PERI1,PERI2] = @dep_three_cmp_cl{
        dose: @bolus{amt:c[AMT]},
        KA: m[KA],
        CL: m[CL], V1: m[V1],
        Q2: m[Q2], V2: m[V2],
        Q3: m[Q3], V3: m[V3]}

The Nonmem parameters are mapped to PoPy as follows:-

  • KA -> KA
  • CL -> CL
  • V2 -> V1
  • Q3 -> Q2
  • V3 -> V2
  • Q4 -> Q3
  • V4 -> V3

Note PoPy uses consistent parameter names between @iv_three_cmp_cl (advan11 trans 4) and @dep_three_cmp_cl (advan12 trans4), whereas Nonmem renumbers the parameters.

See @dep_three_cmp_cl.

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