Introducing PoPy¶

Overview¶

PoPy is a Python based PK/PD (pharmacokinetic/pharmacodynamic) modelling system.

PoPy’s features include:-

Nonlinear mixed-effect models
Bolus and infusion dosing regimens
Inter-occasion variability
Continuous and categorical likelihoods
PK and PD models

PoPy consists of a powerful set of Command Line Tools and script files, to enable you to analyse a PK/PD data file quickly and efficiently, whilst minisimising errors due to an elegant and intuitive syntax.

PoPy makes it easy to fit models to data, but also has the ability to generate new data to test hypothetical scenarios.

Documentation Structure¶

See Table 1 for layout of this documentation:-

Table 1 PoPy Documentation Structure¶
Section	Contents
Getting Started Guide	Read this first to get familiar with PoPy
Principles of Pharmacokinetics	A summary of individual PK/PD models using PoPy syntax
Population Models in PoPy	A summary of population PK models using PoPy syntax
PoPy Example Models	Examples of using PoPy for PK/PD analysis
PoPy for Nonmem Users	Guidance for converting Nonmem examples to PoPy
PoPy Reference Guide	A comprehensive reference on PoPy tools and scripts
Appendices	Links to PK/PD terms used throughout this guide.

System Requirements¶

PoPy is currently available as a 64 bit Microsoft Windows binary. See Table 2:-

Table 2 System Requirements for PoPy¶
Operating System	Microsoft Windows 7.0/8.0/10.0
Disk Space Required	1.5Gb
Bit Size	64
Processor	Intel Core i3 and better recommended
Binary Installer Size	~250Mb