• Language: en

Sine circadian model

[Generated automatically as a Generation summary]

Model Description

Name:

circ_sin

Title:

Sine circadian model

Author:

PoPy for PK/PD

Abstract:

A PD Model based on the amount of drug in the body.
The PD model uses a sine function which simulates a circadian rhythm for the generation of a biomarker.
The amount in the central compartment is determined by CL and V, PK patameters , which have been previosly estimated for each individual.
The amount in the central compartment influences the rate of production of a biomarker.
Keywords:

PD; Pharmacodynamics; sine function; Circadian rhythm

Input Script:

circ_sin_gen.pyml

Diagram:

Outputs

Population simulated (sim) plots

indOBS_vs_TIME

Generated parameter .csv files

Fixed Effects:

fx_params.csv (gen)

Random Effects:

rx_params.csv (gen)

Model params:

mx_params.csv (gen)

State values:

sx_params.csv (gen)

Predictions:

px_params.csv (gen)

Observations:

synthetic_data.csv (gen)

Inputs

True f[X] values (for simulation)

f[AMP] = 2.0000
f[INT] = 8.0000
f[KOUT] = 0.0500
f[ANOISE] = 3.0000
Back to Top