Depot + One compartment PK with BLQ¶
[Generated automatically as a Fitting summary]
Inputs¶
Description¶
Name: | blq_pk |
---|---|
Title: | Depot + One compartment PK with BLQ |
Author: | J.R. Hartley |
Abstract: |
Depot One Comp PK model, with BLQ (below level of quantification) observations.
Keywords: | tutorial; pk; advan4; dep_two_cmp; blq |
---|---|
Input Script: | blq_pk_fit.pyml |
Input Data: | synthetic_data.csv |
Diagram: |
Initial fixed effect estimates¶
f[KA] = 1.0000
f[CL] = 1.0000
f[V1] = 20.0000
f[KA_isv,CL_isv,V1_isv] = [
[ 0.0500, 0.0100, 0.0100 ],
[ 0.0100, 0.0500, 0.0100 ],
[ 0.0100, 0.0100, 0.0500 ],
]
f[PNOISE] = 0.1000
f[ANOISE] = 0.0100
Outputs¶
Final fitted fixed effects¶
f[KA] = 0.2224
f[CL] = 1.9543
f[V1] = 51.0073
f[KA_isv,CL_isv,V1_isv] = [
[ 0.0697, 0.0196, 0.0527 ],
[ 0.0196, 0.0115, 0.0117 ],
[ 0.0527, 0.0117, 0.1872 ],
]
f[PNOISE] = 0.1473
f[ANOISE] = 0.0100
Fitted parameter .csv files¶
Fixed Effects: | fx_params.csv (fit) |
---|---|
Random Effects: | rx_params.csv (fit) |
Model params: | mx_params.csv (fit) |
State values: | sx_params.csv (fit) |
Predictions: | px_params.csv (fit) |
Plots¶
Comparison¶
Compare Main f[X]¶
Variable Name | Fitted Value | Starting Value | Prop Change | Abs Change |
---|---|---|---|---|
f[KA] | 0.2224 | 1.0000 | 0.7776 | 0.7776 |
f[CL] | 1.9543 | 1.0000 | 0.9543 | 0.9543 |
f[V1] | 51.0073 | 20.0000 | 1.5504 | 31.0073 |
Compare Noise f[X]¶
Variable Name | Fitted Value | Starting Value | Prop Change | Abs Change |
---|---|---|---|---|
f[PNOISE] | 0.1473 | 0.1000 | 0.4735 | 0.0473 |
Compare Variance f[X]¶
Variable Name | Fitted Value | Starting Value | Prop Change | Abs Change |
---|---|---|---|---|
f[KA_isv] | 0.0697 | 0.0500 | 0.3947 | 0.0197 |
f[KA_isv;CL_isv] | 0.0196 | 0.0100 | 0.9568 | 0.0096 |
f[KA_isv;V1_isv] | 0.0527 | 0.0100 | 4.2744 | 0.0427 |
f[CL_isv;KA_isv] | 0.0196 | 0.0100 | 0.9568 | 0.0096 |
f[CL_isv] | 0.0115 | 0.0500 | 0.7697 | 0.0385 |
f[CL_isv;V1_isv] | 0.0117 | 0.0100 | 0.1715 | 0.0017 |
f[V1_isv;KA_isv] | 0.0527 | 0.0100 | 4.2744 | 0.0427 |
f[V1_isv;CL_isv] | 0.0117 | 0.0100 | 0.1715 | 0.0017 |
f[V1_isv] | 0.1872 | 0.0500 | 2.7431 | 0.1372 |