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One Compartment Model with Absorption estimating KA, V and CL

[Generated automatically as a Fitting summary]

Inputs

Description

Name:d1cmp_ka_v_cl_stderr
Title:One Compartment Model with Absorption estimating KA, V and CL
Author:Wright Dose Ltd
Abstract:
One Compartment Model with Absorption compartment with rate (KA).
Elimination rate parametrised by clearance (CL)
and volume of distribution (V).
Model specification uses incremental flows
Keywords:dep_one_cmp_cl; one compartment model
Input Script:d1cmp_ka_v_cl_stderr_fit.pyml
Input Data:synthetic_data.csv
Diagram:

Initial fixed effect estimates

f[KA] = 0.3000
f[V] = 20.0000
f[CL] = 3.0000

Outputs

Final objective value

-44.7678

which required 1.7 iterations and took 0.42 seconds

Final fitted fixed effects

f[KA] = 0.2738
f[V] = 17.9983
f[CL] = 3.2389

Fitted parameter .csv files

Fixed Effects:fx_params.csv (fit)
Random Effects:rx_params.csv (fit)
Model params:mx_params.csv (fit)
State values:sx_params.csv (fit)
Predictions:px_params.csv (fit)

Plots

Dense sim plots

Alternatively see All dense_sim graph plots

Comparison

Compare Main f[X]

Variable Name Starting Value Fitted Value Prop Change Abs Change
f[KA] 0.3000 0.2738 0.0872 0.0262
f[V] 20.0000 17.9983 0.1001 2.0017
f[CL] 3.0000 3.2389 0.0796 0.2389

Compare Noise f[X]

Compare Variance f[X]

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