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Diagonal matrix generation diagonal matrix fit

[Generated automatically as a Fitting summary]

Inputs

Description

Name:gen_diag_fit_diag
Title:Diagonal matrix generation diagonal matrix fit
Author:Wright Dose Ltd
Abstract:
One compartment model with absorption compartment and CL/V parametrisation.
This script uses a diagonal covariance matrix to generate the data and a diagonal covariance matrix to fit.
Keywords:one compartment model; dep_one_cmp_cl; diagonal matrix
Input Script:gen_diag_fit_diag_fit.pyml
Input Data:synthetic_data.csv
Diagram:

Initial fixed effect estimates

f[KA] = 0.3000
f[CL] = 3.0000
f[V] = 20.0000
f[PNOISE_STD] = 0.1000
f[ANOISE_STD] = 0.0500
f[CL_isv,V_isv] = [
    [ 0.0100, 0.0000 ],
    [ 0.0000, 0.0100 ],
]

Outputs

Final objective value

-2215.9658

which required 1.9 iterations and took 807.96 seconds

Final fitted fixed effects

f[KA] = 0.3000
f[CL] = 3.0000
f[V] = 20.0000
f[PNOISE_STD] = 0.1000
f[ANOISE_STD] = 0.0500
f[CL_isv,V_isv] = [
    [ 0.1977, 0.0000 ],
    [ 0.0000, 0.1167 ],
]

Fitted parameter .csv files

Fixed Effects:fx_params.csv (fit)
Random Effects:rx_params.csv (fit)
Model params:mx_params.csv (fit)
State values:sx_params.csv (fit)
Predictions:px_params.csv (fit)

Plots

Dense sim plots

Alternatively see All dense_sim graph plots

Comparison

Compare Main f[X]

Compare Noise f[X]

Compare Variance f[X]

Variable Name Starting Value Fitted Value Prop Change Abs Change
f[CL_isv] 0.0100 0.1977 18.7723 0.1877
f[CL_isv;V_isv] 0.0000 0.0000 INF 0.0000
f[V_isv;CL_isv] 0.0000 0.0000 INF 0.0000
f[V_isv] 0.0100 0.1167 10.6701 0.1067
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