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One Compartment Model with Absorption and Inter-subject Variance f[CL_isv]=0.2

[Generated automatically as a Tutorial summary]

Model Description

Name:d1cmp_cl_isv
Title:One Compartment Model with Absorption and Inter-subject Variance f[CL_isv]=0.2
Author:PoPy for PK/PD
Abstract:
Population one Compartment Model with Absorption and Inter-subject Variance
Keywords:one compartment model; dep_one_cmp_cl
Input Script:d1cmp_cl_isv.pyml
Diagram:

Comparison

True objective value

-389.4976

Final fitted objective value

-394.5899

Compare Main f[X]

Name Initial Fitted True Abs. Error Prop. Error
f[KA] 0.5 0.302 0.3 1.91e-03 0.64%
f[CL] 1 3.3 3 2.98e-01 9.95%
f[V] 15 19.6 20 3.51e-01 1.76%

Compare Noise f[X]

Name Initial Fitted True Abs. Error Prop. Error
f[PNOISE_STD] 0.2 0.0712 0.1 2.88e-02 28.79%
f[ANOISE_STD] 0.2 0.0545 0.05 4.48e-03 8.96%

Compare Variance f[X]

Name Initial Fitted True Abs. Error Prop. Error
f[CL_isv] 0.01 0.184 0.2 1.57e-02 7.84%

Outputs

Fitted f[X] values (after fitting)

f[KA] = 0.3019
f[CL] = 3.2984
f[V] = 19.6487
f[PNOISE_STD] = 0.0712
f[ANOISE_STD] = 0.0545
f[CL_isv] = 0.1843

Generated data .csv file

Synthetic Data:synthetic_data.csv

Inputs

True f[X] values (for simulation)

f[KA] = 0.3000
f[CL] = 3.0000
f[V] = 20.0000
f[PNOISE_STD] = 0.1000
f[ANOISE_STD] = 0.0500
f[CL_isv] = 0.2000

Starting f[X] values (before fitting)

f[KA] = 0.5000
f[CL] = 1.0000
f[V] = 15.0000
f[PNOISE_STD] = 0.2000
f[ANOISE_STD] = 0.2000
f[CL_isv] = 0.0100
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