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One Compartment Model with Absorption and Inter-subject Variance f[CL_isv]=0.2

[Generated automatically as a Tutorial summary]

Model Description

Name:d1cmp_cl_isv
Title:One Compartment Model with Absorption and Inter-subject Variance f[CL_isv]=0.2
Author:PoPy for PK/PD
Abstract:
Population one Compartment Model with Absorption and Inter-subject Variance
Keywords:one compartment model; dep_one_cmp_cl
Input Script:d1cmp_cl_isv.pyml
Diagram:

Comparison

True objective value

-417.7570

Final fitted objective value

-430.9290

Compare Main f[X]

Name Initial Fitted True Abs. Error Prop. Error
f[KA] 0.5 0.28 0.3 1.98e-02 6.60%
f[CL] 1 3.23 3 2.27e-01 7.58%
f[V] 15 19.8 20 1.61e-01 0.80%

Compare Noise f[X]

Name Initial Fitted True Abs. Error Prop. Error
f[PNOISE_STD] 0.2 0.0809 0.1 1.91e-02 19.05%
f[ANOISE_STD] 0.2 0.0373 0.05 1.27e-02 25.37%

Compare Variance f[X]

Name Initial Fitted True Abs. Error Prop. Error
f[CL_isv] 0.01 0.177 0.2 2.34e-02 11.72%

Outputs

Fitted f[X] values (after fitting)

f[KA] = 0.2802
f[CL] = 3.2273
f[V] = 19.8391
f[PNOISE_STD] = 0.0809
f[ANOISE_STD] = 0.0373
f[CL_isv] = 0.1766

Generated data .csv file

Synthetic Data:synthetic_data.csv

Inputs

True f[X] values (for simulation)

f[KA] = 0.3000
f[CL] = 3.0000
f[V] = 20.0000
f[PNOISE_STD] = 0.1000
f[ANOISE_STD] = 0.0500
f[CL_isv] = 0.2000

Starting f[X] values (before fitting)

f[KA] = 0.5000
f[CL] = 1.0000
f[V] = 15.0000
f[PNOISE_STD] = 0.2000
f[ANOISE_STD] = 0.2000
f[CL_isv] = 0.0100
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