ADVAN1¶

In Nonmem:-

$SUBROUTINES  ADVAN1

With following parameters defined in the Nonmem $PK section:-

• K = elimination rate

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[CEN] = @iv_one_cmp_k{dose: @bolus{amt:c[AMT]}, KE: m[KE]}

The Nonmem parameters are mapped to PoPy as follows:-

• K -> KE

See @iv_one_cmp_k.

ADVAN1 TRANS2¶

In Nonmem:-

$SUBROUTINES  ADVAN1 TRAN2

With following parameters defined in the Nonmem $PK section:-

• CL = clearance
• V = volume of distribution

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[CEN] = @iv_one_cmp_cl{dose: @bolus{amt:c[AMT]}, CL: m[CL], V: m[V]}

The Nonmem parameters are mapped to PoPy as follows:-

• CL -> CL
• V -> V

See @iv_one_cmp_cl.

ADVAN2¶

In Nonmem:-

$SUBROUTINES  ADVAN2

With following parameters defined in the Nonmem $PK section:-

• KA = absorption rate
• K = elimination rate

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[DEP,CEN] = @dep_one_cmp_k{dose: @bolus{amt:c[AMT]}, KA: m[KA], KE: m[KE]}

The Nonmem parameters are mapped to PoPy as follows:-

• KA -> KA
• K -> KE

See @dep_one_cmp_k.

ADVAN2 TRANS2¶

In Nonmem:-

$SUBROUTINES  ADVAN2 TRAN2

With following parameters defined in the Nonmem $PK section:-

• KA = absorption rate
• CL = clearance
• V = volume of distribution

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[DEP,CEN] = @dep_one_cmp_cl{
        dose: @bolus{amt:c[AMT]},
        KA: m[KA], CL: m[CL], V: m[V]
    }

The Nonmem parameters are mapped to PoPy as follows:-

• KA -> KA
• CL -> CL
• V -> V

See @dep_one_cmp_cl.

ADVAN3¶

In Nonmem:-

$SUBROUTINES  ADVAN3

With following parameters defined in the Nonmem $PK section:-

• K = elimination rate from central compartment
• K12 = elimination rate from central to peripheral compartment
• K21 = elimination rate from peripheral to central compartment

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[CEN,PERI] = @iv_two_cmp_k{
        dose: @bolus{amt:c[AMT]},
        KE: m[KE], K12: m[K12], K21: m[K21]}

The Nonmem parameters are mapped to PoPy as follows:-

• K -> KE
• K12 -> K12
• K21 -> K21

See @iv_two_cmp_k.

ADVAN3 TRANS4¶

In Nonmem:-

$SUBROUTINES  ADVAN3 TRANS4

With following parameters defined in the Nonmem $PK section:-

• CL = clearance from central compartment
• V1 = volume of distribution for central compartment
• Q = clearance between central and peripheral compartment
• V2 = volume of distribution for peripheral compartment

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[CEN,PERI] = @iv_two_cmp_cl{
        dose: @bolus{amt:c[AMT]},
        CL: m[CL], V1: m[V1], Q: m[Q], V2: m[V2]}

The Nonmem parameters are mapped to PoPy as follows:-

• CL -> CL
• V1 -> V1
• Q -> Q
• V2 -> V2

See @iv_two_cmp_cl.

ADVAN4¶

In Nonmem:-

$SUBROUTINES  ADVAN4

With following parameters defined in the Nonmem $PK section:-

• KA = absorption rate from depot to central compartment
• K = elimination rate from central compartment
• K23 = elimination rate from central to peripheral compartment
• K32 = elimination rate from peripheral to central compartment

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[DEP,CEN,PERI] = @dep_two_cmp_k{
        dose: @bolus{amt:c[AMT]},
        KA: m[KA], KE: m[KE], K12: m[K12], K21: m[K21]}

The Nonmem parameters are mapped to PoPy as follows:-

• KA -> KA
• K -> KE
• K23 -> K12
• K32 -> K21

Note PoPy uses consistent parameter names between @iv_two_cmp_k (advan3) and @dep_two_cmp_k (advan4), whereas Nonmem renumbers the parameters.

See @dep_two_cmp_k.

ADVAN4 TRANS4¶

In Nonmem:-

$SUBROUTINES  ADVAN4 TRANS4

With following parameters defined in the Nonmem $PK section:-

• KA = absorption rate from depot to central compartment
• CL = clearance from central compartment
• V2 = volume of distribution for central compartment
• Q = clearance between central and peripheral compartment
• V3 = volume of distribution for peripheral compartment

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[DEP,CEN,PERI] = @dep_two_cmp_cl{
        dose: @bolus{amt:c[AMT]},
        KA: m[KA], CL: m[CL], V1: m[V1],
        Q: m[Q], V2: m[V2]}

The Nonmem parameters are mapped to PoPy as follows:-

• KA -> KA
• CL -> CL
• V2 -> V1
• Q -> Q
• V3 -> V2

Note PoPy uses consistent parameter names between @iv_two_cmp_cl (advan3 trans 4) and @dep_two_cmp_cl (advan4 trans4), whereas Nonmem renumbers the parameters.

See @dep_two_cmp_cl.

ADVAN11¶

In Nonmem:-

$SUBROUTINES  ADVAN11

With following parameters defined in the Nonmem $PK section:-

• K = elimination rate from central compartment
• K12 = elimination rate from central to first peripheral compartment
• K21 = elimination rate from first peripheral to central compartment
• K13 = elimination rate from central to second peripheral compartment
• K31 = elimination rate from second peripheral to central compartment

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[CEN,PERI1,PERI2] = @iv_three_cmp_k{
        dose: @bolus{amt:c[AMT]},
        KE: m[KE], K12: m[K12], K21: m[K21],
        K13: m[K13], K31: m[K31]}

The Nonmem parameters are mapped to PoPy as follows:-

• K -> KE
• K12 -> K12
• K21 -> K21
• K13 -> K13
• K31 -> K31

See @iv_three_cmp_k.

ADVAN11 TRANS4¶

In Nonmem:-

$SUBROUTINES  ADVAN11 TRANS4

With following parameters defined in the Nonmem $PK section:-

• CL = clearance from central compartment
• V1 = volume of distribution for central compartment
• Q2 = clearance between central and first peripheral compartment
• V2 = volume of distribution for first peripheral compartment
• Q3 = clearance between central and first peripheral compartment
• V3 = volume of distribution for second peripheral compartment

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[CEN,PERI1,PERI2] = @iv_three_cmp_cl{
        dose: @bolus{amt:c[AMT]},
        CL: m[CL], V1: m[V1], Q2: m[Q2],
        V2: m[V2], Q3: m[Q3], V3: m[V3]}

The Nonmem parameters are mapped to PoPy as follows:-

• CL -> CL
• V1 -> V1
• Q2 -> Q2
• V2 -> V2
• Q3 -> Q3
• V3 -> V3

See @iv_three_cmp_cl.

ADVAN12¶

In Nonmem:-

$SUBROUTINES  ADVAN12

With following parameters defined in the Nonmem $PK section:-

• KA = absorption rate from depot to central compartment
• K = elimination rate from central compartment
• K23 = elimination rate from central to first peripheral compartment
• K32 = elimination rate from first peripheral to central compartment
• K24 = elimination rate from central to second peripheral compartment
• K42 = elimination rate from second peripheral to central compartment

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[DEP,CEN,PERI1,PERI2] = @dep_three_cmp_k{
        dose: @bolus{amt:c[AMT]},
        KA: m[KA], KE: m[KE],
        K12: m[K12], K21: m[K21],
        K13: m[K13], K31: m[K31]}

The Nonmem parameters are mapped to PoPy as follows:-

• KA -> KA
• K -> KE
• K23 -> K12
• K32 -> K21
• K24 -> K13
• K42 -> K31

Note PoPy uses consistent parameter names between @iv_three_cmp_k (advan11) and @dep_three_cmp_k (advan12), whereas Nonmem renumbers the parameters.

See @dep_three_cmp_k.

ADVAN12 TRANS4¶

In Nonmem:-

$SUBROUTINES  ADVAN12 TRANS4

With following parameters defined in the Nonmem $PK section:-

• KA = absorption rate from depot to central compartment
• CL = clearance from central compartment
• V2 = volume of distribution for central compartment
• Q3 = clearance between central and first peripheral compartment
• V3 = volume of distribution for first peripheral compartment
• Q4 = clearance between central and first peripheral compartment
• V4 = volume of distribution for second peripheral compartment

Equivalent PoPy DERIVATIVES section:-

DERIVATIVES: |
    s[DEP,CEN,PERI1,PERI2] = @dep_three_cmp_cl{
        dose: @bolus{amt:c[AMT]},
        KA: m[KA],
        CL: m[CL], V1: m[V1],
        Q2: m[Q2], V2: m[V2],
        Q3: m[Q3], V3: m[V3]}

The Nonmem parameters are mapped to PoPy as follows:-

• KA -> KA
• CL -> CL
• V2 -> V1
• Q3 -> Q2
• V3 -> V2
• Q4 -> Q3
• V4 -> V3

Note PoPy uses consistent parameter names between @iv_three_cmp_cl (advan11 trans 4) and @dep_three_cmp_cl (advan12 trans4), whereas Nonmem renumbers the parameters.

See @dep_three_cmp_cl.