- Language: en
- Documentation version: 1.3.1
emax_marker_model
[Generated automatically as a Tutorial summary]
Model Description
- Name:
emax_biomarker
- Title:
emax_marker_model
- Author:
PoPy for PK/PD
- Abstract:
An emax Model, based on the concentration of drug in the central compartment.
The amount in the central compartment is determined by CL/V, which has been estimated for each individual.
The concentration in the central compartment influences the rate of removal of a biomarker (KOUT).
- Keywords:
PD; Pharmacodynamics; one compartment model; KIN; KOUT; emax; biomarker
- Input Script:
- Diagram:
Comparison
True objective value
86.0288
Final fitted objective value
193.0522
Compare Main f[X]
Name |
Initial |
Fitted |
True |
Abs. Error |
Prop. Error |
|---|---|---|---|---|---|
f[KIN] |
15 |
87.8 |
10 |
7.78e+01 |
778.47% |
f[KOUT] |
0.1 |
0.049 |
0.05 |
9.90e-04 |
1.98% |
f[EMAX] |
90 |
27.3 |
80 |
5.27e+01 |
65.84% |
f[E50] |
25 |
95.9 |
30 |
6.59e+01 |
219.82% |
Compare Noise f[X]
Name |
Initial |
Fitted |
True |
Abs. Error |
Prop. Error |
|---|---|---|---|---|---|
f[ANOISE] |
5 |
1.61 |
1 |
6.07e-01 |
60.65% |
Compare Variance f[X]
No Variance f[X] values to compare.
Outputs
Fitted f[X] values (after fitting)
f[KIN] = 87.8471
f[KOUT] = 0.0490
f[EMAX] = 27.3312
f[E50] = 95.9468
f[ANOISE] = 1.6065
Generated data .csv file
- Synthetic Data:
Gen and Fit Summaries
Gen: emax_marker_model (gen)
Fit: emax_marker_model (fit)
Inputs
True f[X] values (for simulation)
f[KIN] = 10.0000
f[KOUT] = 0.0500
f[EMAX] = 80.0000
f[E50] = 30.0000
f[ANOISE] = 1.0000
Starting f[X] values (before fitting)
f[KIN] = 15.0000
f[KOUT] = 0.1000
f[EMAX] = 90.0000
f[E50] = 25.0000
f[ANOISE] = 5.0000