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  • Documentation version: 1.3.1

Complex Emax PD Model

[Generated automatically as a Generation summary]

Model Description

Name:

emax_complex

Title:

Complex Emax PD Model

Author:

PoPy for PK/PD

Abstract:

An complex emax PK/PD Model, based on the concentration of drug in the body.
The two compartment PK model uses previously estimated values of CL, V1, Q and V2 for each individual
The concentration in the central compartment influences the effect compartment along with EMAX (the maximum effect), EC50 (the concentration at which the effect is half the maximum) using a hill equation.
Keywords:

pkpd

Input Script:

emax_complex_gen.pyml

Diagram:

Outputs

Population simulated (sim) plots

indOBS_vs_TIME

Generated parameter .csv files

Fixed Effects:

fx_params.csv (gen)

Random Effects:

rx_params.csv (gen)

Model params:

mx_params.csv (gen)

State values:

sx_params.csv (gen)

Predictions:

px_params.csv (gen)

Observations:

synthetic_data.csv (gen)

Inputs

True f[X] values (for simulation)

f[EMAX] = 80.0000
f[E50] = 20.0000
f[GAMMA] = 0.5000
f[ANOISE] = 3.0000
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