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  • Documentation version: 1.3.1

Direct Effect Emax PD Model

[Generated automatically as a Generation summary]

Model Description

Name:

emax_nondiff

Title:

Direct Effect Emax PD Model

Author:

PoPy for PK/PD

Abstract:

A direct effect emax PK/PD Model, based on the concentration of drug in the body.
The one compartment PK model uses previously estimated values of CL and V for each individual
The concentration in the central compartment influences the effect.
The effect is not a compartment and so does not increase over time. It is dependent on the baseline effect, the concentration in the central compartment, the maximum effect (emax) and concentration at which the effect is half the maximum (EC50).
Keywords:

PD; Pharmacodynamics; one compartment model; emax; EC50; baseline effect

Input Script:

emax_nondiff_gen.pyml

Diagram:

Outputs

Population simulated (sim) plots

indOBS_vs_TIME

Generated parameter .csv files

Fixed Effects:

fx_params.csv (gen)

Random Effects:

rx_params.csv (gen)

Model params:

mx_params.csv (gen)

State values:

sx_params.csv (gen)

Predictions:

px_params.csv (gen)

Observations:

synthetic_data.csv (gen)

Inputs

True f[X] values (for simulation)

f[EMAX] = 100.0000
f[E50] = 60.0000
f[EBASE] = 10.0000
f[ANOISE] = 0.5000
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