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  • Documentation version: 1.3.1

Emax PD Model

[Generated automatically as a Generation summary]

Model Description

Name:

emax_simple

Title:

Emax PD Model

Author:

PoPy for PK/PD

Abstract:

A simple emax PKPD Model, based on the amount of drug in the body.
The two compartment PK model uses previously estimated values of K, K21 and K12 for each individual
The amount in the central compartment influences the effect compartment along with EMAX (the maximum effect) and EC50 (the amount at which the effect is half the maximum)
Keywords:

PD; Pharmacodynamics; two compartment model; emax; EC50

Input Script:

emax_simple_gen.pyml

Diagram:

Outputs

Population simulated (sim) plots

indOBS_vs_TIME

Generated parameter .csv files

Fixed Effects:

fx_params.csv (gen)

Random Effects:

rx_params.csv (gen)

Model params:

mx_params.csv (gen)

State values:

sx_params.csv (gen)

Predictions:

px_params.csv (gen)

Observations:

synthetic_data.csv (gen)

Inputs

True f[X] values (for simulation)

f[EMAX] = 80.0000
f[E50] = 20.0000
f[ANOISE] = 1.0000
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