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  • Documentation version: 1.3.1

One Compartment Model with Absorption and Inter-occasion Variance f[CL_isv]=0.2

[Generated automatically as a Fitting summary]

Model Description

Name:

d1cmp_cl_iov

Title:

One Compartment Model with Absorption and Inter-occasion Variance f[CL_isv]=0.2

Author:

PoPy for PK/PD

Abstract:

Population one Compartment Model with Absorption and Inter-occasion Variance
Keywords:

one compartment model; dep_one_cmp_cl; iov

Input Script:

d1cmp_cl_iov_fit.pyml

Diagram:

Comparison

Compare Main f[X]

Variable Name

Starting Value

Fitted Value

Abs Change

Prop Change

f[KA]

0.5000

0.3345

0.1655

0.3309

f[CL]

1.0000

2.5855

1.5855

1.5855

f[V]

15.0000

20.2051

5.2051

0.3470

Compare Noise f[X]

Variable Name

Starting Value

Fitted Value

Abs Change

Prop Change

f[PNOISE_STD]

0.2000

0.1000

0.1000

0.4998

f[ANOISE_STD]

0.2000

0.0479

0.1521

0.7605

Compare Variance f[X]

Variable Name

Starting Value

Fitted Value

Abs Change

Prop Change

f[CL_isv]

0.0100

0.1200

0.1100

10.9960

f[CL_iov]

0.0100

0.0783

0.0683

6.8312

Individual simulated (sim) plots

Alternatively see All simulated_sim graph plots

Population simulated (sim) plots

allOBS_vs_TIME

Outputs

Final objective value

-363.8118

which required 1.19 iterations and took 46.47 seconds

Fitted f[X] values (after fitting)

f[KA] = 0.3345
f[CL] = 2.5855
f[V] = 20.2051
f[PNOISE_STD] = 0.1000
f[ANOISE_STD] = 0.0479
f[CL_isv] = 0.1200
f[CL_iov] = 0.0783

Fitted parameter .csv files

Fixed Effects:

fx_params.csv (fit)

Random Effects:

rx_params.csv (fit)

Model params:

mx_params.csv (fit)

State values:

sx_params.csv (fit)

Predictions:

px_params.csv (fit)

Likelihoods:

lx_params.csv (fit)

Inputs

Input Data:

cx_obs_params.csv

Starting f[X] values (before fitting)

f[KA] = 0.5000
f[CL] = 1.0000
f[V] = 15.0000
f[PNOISE_STD] = 0.2000
f[ANOISE_STD] = 0.2000
f[CL_isv] = 0.0100
f[CL_iov] = 0.0100
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