- Language: en
Direct PD Model Simultaneous PK/PD Parameter fit¶
[Generated automatically as a Tutorial summary]
Inputs¶
Description¶
| Name: | direct_pd_simul |
|---|---|
| Title: | Direct PD Model Simultaneous PK/PD Parameter fit |
| Author: | Wright Dose Ltd |
| Abstract: |
A simple direct PD Model, based on the amount of drug in the body. That simultaneously fits PK and PD parameters.
The amount in the central compartment is determined by K, which has been previously estimated for each individual.
The amount in the central compartment influences the rate of removal of a biomarker (KOUT).
| Keywords: | pd; one compartment model; direct |
|---|---|
| Input Script: | direct_pd_simul_tut.pyml |
| Diagram: |
Failed to create compartment diagram
True f[X] values¶
f[CL] = 2
f[V] = 50
f[BASE] = 800
f[KOUT] = 0.03
f[PK_ANOISE] = 0.5
f[PD_ANOISE] = 0.3
Starting f[X] values¶
f[CL] = 5
f[V] = 15
f[BASE] = 500
f[KOUT] = 0.1
f[PK_ANOISE] = 5
f[PD_ANOISE] = 5
Outputs¶
Generating and Fitting Summaries¶
Fitted f[X] values¶
f[CL] = 1.9992
f[V] = 51.005
f[BASE] = 799.98
f[KOUT] = 0.030588
f[PK_ANOISE] = 0.49676
f[PD_ANOISE] = 0.25265
Plots¶
Comparison¶
True objective value¶
-203.759528569
Final fitted objective value¶
-208.115820594
Compare Main f[X]¶
| Name | Initial | Fitted | True | Prop. Error | Abs. Error |
|---|---|---|---|---|---|
| f[CL] | 5 | 2… | 2 | 0.04% | 8.45e-04 |
| f[V] | 15 | 51 | 50 | 2.01% | 1.01e+00 |
| f[BASE] | 500 | 800… | 800 | 0.00% | 2.34e-02 |
| f[KOUT] | 0.1 | 0.0306 | 0.03 | 1.96% | 5.88e-04 |
Compare Noise f[X]¶
| Name | Initial | Fitted | True | Prop. Error | Abs. Error |
|---|---|---|---|---|---|
| f[PK_ANOISE] | 5 | 0.497 | 0.5 | 0.65% | 3.24e-03 |
| f[PD_ANOISE] | 5 | 0.253 | 0.3 | 15.78% | 4.74e-02 |
Compare Variance f[X]¶
No Variance f[X] values to compare.