- Language: en
Direct PD Model Simultaneous PK/PD Parameter fit¶
[Generated automatically as a Tutorial summary]
Inputs¶
Description¶
| Name: | direct_pd_simul |
|---|---|
| Title: | Direct PD Model Simultaneous PK/PD Parameter fit |
| Author: | Wright Dose Ltd |
| Abstract: |
A simple direct PD Model, based on the amount of drug in the body. That simultaneously fits PK and PD parameters.
The amount in the central compartment is determined by K, which has been previously estimated for each individual.
The amount in the central compartment influences the rate of removal of a biomarker (KOUT).
| Keywords: | pd; one compartment model; direct |
|---|---|
| Input Script: | direct_pd_simul_tut.pyml |
| Diagram: |
True f[X] values¶
f[CL] = 2.0000
f[V] = 50.0000
f[BASE] = 800.0000
f[KOUT] = 0.0300
f[PK_ANOISE] = 0.5000
f[PD_ANOISE] = 0.3000
Starting f[X] values¶
f[CL] = 5.0000
f[V] = 15.0000
f[BASE] = 500.0000
f[KOUT] = 0.1000
f[PK_ANOISE] = 5.0000
f[PD_ANOISE] = 5.0000
Outputs¶
Generating and Fitting Summaries¶
Fitted f[X] values¶
f[CL] = 1.9902
f[V] = 50.9565
f[BASE] = 800.8914
f[KOUT] = 0.0306
f[PK_ANOISE] = 0.5073
f[PD_ANOISE] = 10.0000
Plots¶
Comparison¶
True objective value¶
-203.7595
Final fitted objective value¶
424.9294
Compare Main f[X]¶
| Name | Initial | Fitted | True | Prop. Error | Abs. Error |
|---|---|---|---|---|---|
| f[CL] | 5 | 1.99 | 2 | 0.49% | 9.81e-03 |
| f[V] | 15 | 51 | 50 | 1.91% | 9.56e-01 |
| f[BASE] | 500 | 801 | 800 | 0.11% | 8.91e-01 |
| f[KOUT] | 0.1 | 0.0306 | 0.03 | 2.07% | 6.20e-04 |
Compare Noise f[X]¶
| Name | Initial | Fitted | True | Prop. Error | Abs. Error |
|---|---|---|---|---|---|
| f[PK_ANOISE] | 5 | 0.507 | 0.5 | 1.47% | 7.35e-03 |
| f[PD_ANOISE] | 5 | 10 | 0.3 | 3233.33% | 9.70e+00 |
Compare Variance f[X]¶
No Variance f[X] values to compare.