Direct PD Model Simultaneous PK/PD Parameter fit
[Generated automatically as a Tutorial summary]
Model Description
- Name:
direct_pd_simul
- Title:
Direct PD Model Simultaneous PK/PD Parameter fit
- Author:
PoPy for PK/PD
- Abstract:
A simple direct PD Model, based on the amount of drug in the body. That simultaneously fits PK and PD parameters.
The amount in the central compartment is determined by K, which has been previously estimated for each individual.
The amount in the central compartment influences the rate of removal of a biomarker (KOUT).
- Keywords:
pd; one compartment model; direct
- Input Script:
- Diagram:
Comparison
True objective value
-203.7595
Final fitted objective value
386.6144
Compare Main f[X]
Name |
Initial |
Fitted |
True |
Abs. Error |
Prop. Error |
|---|---|---|---|---|---|
f[CL] |
5 |
2… |
2 |
1.94e-03 |
0.10% |
f[V] |
15 |
48.1 |
50 |
1.91e+00 |
3.81% |
f[BASE] |
500 |
799 |
800 |
7.71e-01 |
0.10% |
f[KOUT] |
0.1 |
0.0288 |
0.03 |
1.23e-03 |
4.10% |
Compare Noise f[X]
Name |
Initial |
Fitted |
True |
Abs. Error |
Prop. Error |
|---|---|---|---|---|---|
f[PK_ANOISE] |
5 |
0.51 |
0.5 |
1.02e-02 |
2.05% |
f[PD_ANOISE] |
5 |
8.23 |
0.3 |
7.93e+00 |
2641.77% |
Compare Variance f[X]
No Variance f[X] values to compare.
Outputs
Fitted f[X] values (after fitting)
f[CL] = 2.0019
f[V] = 48.0926
f[BASE] = 799.2292
f[KOUT] = 0.0288
f[PK_ANOISE] = 0.5102
f[PD_ANOISE] = 8.2253
Generated data .csv file
- Synthetic Data:
Gen and Fit Summaries
Inputs
True f[X] values (for simulation)
f[CL] = 2.0000
f[V] = 50.0000
f[BASE] = 800.0000
f[KOUT] = 0.0300
f[PK_ANOISE] = 0.5000
f[PD_ANOISE] = 0.3000
Starting f[X] values (before fitting)
f[CL] = 5.0000
f[V] = 15.0000
f[BASE] = 500.0000
f[KOUT] = 0.1000
f[PK_ANOISE] = 5.0000
f[PD_ANOISE] = 5.0000