Depot + One compartment PK with BLQ¶
[Generated automatically as a Tutorial summary]
Inputs¶
Description¶
Name: | blq_pk |
---|---|
Title: | Depot + One compartment PK with BLQ |
Author: | J.R. Hartley |
Abstract: |
Depot One Comp PK model, with BLQ (below level of quantification) observations.
Keywords: | tutorial; pk; advan4; dep_two_cmp; blq |
---|---|
Input Script: | blq_pk_tut.pyml |
Diagram: |
True f[X] values¶
f[KA] = 0.2000
f[CL] = 2.0000
f[V1] = 50.0000
f[KA_isv,CL_isv,V1_isv] = [
[ 0.1000, 0.0200, 0.0100 ],
[ 0.0200, 0.0300, 0.0200 ],
[ 0.0100, 0.0200, 0.0900 ],
]
f[PNOISE] = 0.1500
f[ANOISE] = 0.0100
Starting f[X] values¶
f[KA] = 1.0000
f[CL] = 1.0000
f[V1] = 20.0000
f[KA_isv,CL_isv,V1_isv] = [
[ 0.0500, 0.0100, 0.0100 ],
[ 0.0100, 0.0500, 0.0100 ],
[ 0.0100, 0.0100, 0.0500 ],
]
f[PNOISE] = 0.1000
f[ANOISE] = 0.0100
Outputs¶
Generating and Fitting Summaries¶
- Gen: Depot + One compartment PK with BLQ (gen)
- Fit: Depot + One compartment PK with BLQ (fit)
Fitted f[X] values¶
f[KA] = 0.2185
f[CL] = 1.9944
f[V1] = 50.4071
f[KA_isv,CL_isv,V1_isv] = [
[ 0.0203, 0.0106, 0.0251 ],
[ 0.0106, 0.0126, 0.0145 ],
[ 0.0251, 0.0145, 0.1816 ],
]
f[PNOISE] = 0.1509
f[ANOISE] = 0.0100
Plots¶
Comparison¶
True objective value¶
-725.9090
Final fitted objective value¶
-732.3632
Compare Main f[X]¶
Name | Initial | Fitted | True | Prop. Error | Abs. Error |
---|---|---|---|---|---|
f[KA] | 1 | 0.219 | 0.2 | 9.26% | 1.85e-02 |
f[CL] | 1 | 1.99 | 2 | 0.28% | 5.56e-03 |
f[V1] | 20 | 50.4 | 50 | 0.81% | 4.07e-01 |
Compare Noise f[X]¶
Name | Initial | Fitted | True | Prop. Error | Abs. Error |
---|---|---|---|---|---|
f[PNOISE] | 0.1 | 0.151 | 0.15 | 0.59% | 8.91e-04 |
Compare Variance f[X]¶
Name | Initial | Fitted | True | Prop. Error | Abs. Error |
---|---|---|---|---|---|
f[KA_isv] | 0.05 | 0.0203 | 0.1 | 79.70% | 7.97e-02 |
f[KA_isv;CL_isv] | 0.01 | 0.0106 | 0.02 | 46.80% | 9.36e-03 |
f[KA_isv;V1_isv] | 0.01 | 0.0251 | 0.01 | 151.35% | 1.51e-02 |
f[CL_isv;KA_isv] | 0.01 | 0.0106 | 0.02 | 46.80% | 9.36e-03 |
f[CL_isv] | 0.05 | 0.0126 | 0.03 | 58.11% | 1.74e-02 |
f[CL_isv;V1_isv] | 0.01 | 0.0145 | 0.02 | 27.70% | 5.54e-03 |
f[V1_isv;KA_isv] | 0.01 | 0.0251 | 0.01 | 151.35% | 1.51e-02 |
f[V1_isv;CL_isv] | 0.01 | 0.0145 | 0.02 | 27.70% | 5.54e-03 |
f[V1_isv] | 0.05 | 0.182 | 0.09 | 101.77% | 9.16e-02 |