• Language: en

Depot + One compartment PK with BLQ

[Generated automatically as a Tutorial summary]

Inputs

Description

Name:blq_pk
Title:Depot + One compartment PK with BLQ
Author:J.R. Hartley
Abstract:
Depot One Comp PK model, with BLQ (below level of quantification) observations.
Keywords:tutorial; pk; advan4; dep_two_cmp; blq
Input Script:blq_pk_tut.pyml
Diagram:

True f[X] values

f[KA] = 0.2000
f[CL] = 2.0000
f[V1] = 50.0000
f[KA_isv,CL_isv,V1_isv] = [
    [ 0.1000, 0.0200, 0.0100 ],
    [ 0.0200, 0.0300, 0.0200 ],
    [ 0.0100, 0.0200, 0.0900 ],
]
f[PNOISE] = 0.1500
f[ANOISE] = 0.0100

Starting f[X] values

f[KA] = 1.0000
f[CL] = 1.0000
f[V1] = 20.0000
f[KA_isv,CL_isv,V1_isv] = [
    [ 0.0500, 0.0100, 0.0100 ],
    [ 0.0100, 0.0500, 0.0100 ],
    [ 0.0100, 0.0100, 0.0500 ],
]
f[PNOISE] = 0.1000
f[ANOISE] = 0.0100

Outputs

Generated data .csv file

Synthetic Data:synthetic_data.csv

Generating and Fitting Summaries

Fitted f[X] values

f[KA] = 0.1954
f[CL] = 2.0254
f[V1] = 46.9680
f[KA_isv,CL_isv,V1_isv] = [
    [ 0.1374, 0.0157, 0.0621 ],
    [ 0.0157, 0.0392, 0.0200 ],
    [ 0.0621, 0.0200, 0.1254 ],
]
f[PNOISE] = 0.1389
f[ANOISE] = 0.0100

Plots

Dense comp plots

Alternatively see All dense_comp graph plots

Comparison

True objective value

-756.5645

Final fitted objective value

-763.9922

Compare Main f[X]

Name Initial Fitted True Prop. Error Abs. Error
f[KA] 1 0.195 0.2 2.28% 4.55e-03
f[CL] 1 2.03 2 1.27% 2.54e-02
f[V1] 20 47 50 6.06% 3.03e+00

Compare Noise f[X]

Name Initial Fitted True Prop. Error Abs. Error
f[PNOISE] 0.1 0.139 0.15 7.41% 1.11e-02

Compare Variance f[X]

Name Initial Fitted True Prop. Error Abs. Error
f[KA_isv] 0.05 0.137 0.1 37.43% 3.74e-02
f[KA_isv;CL_isv] 0.01 0.0157 0.02 21.29% 4.26e-03
f[KA_isv;V1_isv] 0.01 0.0621 0.01 521.48% 5.21e-02
f[CL_isv;KA_isv] 0.01 0.0157 0.02 21.29% 4.26e-03
f[CL_isv] 0.05 0.0392 0.03 30.50% 9.15e-03
f[CL_isv;V1_isv] 0.01 0.02… 0.02 0.21% 4.19e-05
f[V1_isv;KA_isv] 0.01 0.0621 0.01 521.48% 5.21e-02
f[V1_isv;CL_isv] 0.01 0.02… 0.02 0.21% 4.19e-05
f[V1_isv] 0.05 0.125 0.09 39.32% 3.54e-02
Back to Top