Depot + One compartment PK with BLQ¶
[Generated automatically as a Tutorial summary]
Inputs¶
Description¶
Name: | blq_pk |
---|---|
Title: | Depot + One compartment PK with BLQ |
Author: | J.R. Hartley |
Abstract: |
Depot One Comp PK model, with BLQ (below level of quantification) observations.
Keywords: | tutorial; pk; advan4; dep_two_cmp; blq |
---|---|
Input Script: | blq_pk_tut.pyml |
Diagram: |
True f[X] values¶
f[KA] = 0.2000
f[CL] = 2.0000
f[V1] = 50.0000
f[KA_isv,CL_isv,V1_isv] = [
[ 0.1000, 0.0200, 0.0100 ],
[ 0.0200, 0.0300, 0.0200 ],
[ 0.0100, 0.0200, 0.0900 ],
]
f[PNOISE] = 0.1500
f[ANOISE] = 0.0100
Starting f[X] values¶
f[KA] = 1.0000
f[CL] = 1.0000
f[V1] = 20.0000
f[KA_isv,CL_isv,V1_isv] = [
[ 0.0500, 0.0100, 0.0100 ],
[ 0.0100, 0.0500, 0.0100 ],
[ 0.0100, 0.0100, 0.0500 ],
]
f[PNOISE] = 0.1000
f[ANOISE] = 0.0100
Outputs¶
Generated data .csv file¶
Synthetic Data: | synthetic_data.csv |
---|
Generating and Fitting Summaries¶
- Gen: Depot + One compartment PK with BLQ (gen)
- Fit: Depot + One compartment PK with BLQ (fit)
Fitted f[X] values¶
f[KA] = 0.1954
f[CL] = 2.0254
f[V1] = 46.9680
f[KA_isv,CL_isv,V1_isv] = [
[ 0.1374, 0.0157, 0.0621 ],
[ 0.0157, 0.0392, 0.0200 ],
[ 0.0621, 0.0200, 0.1254 ],
]
f[PNOISE] = 0.1389
f[ANOISE] = 0.0100
Plots¶
Comparison¶
True objective value¶
-756.5645
Final fitted objective value¶
-763.9922
Compare Main f[X]¶
Name | Initial | Fitted | True | Prop. Error | Abs. Error |
---|---|---|---|---|---|
f[KA] | 1 | 0.195 | 0.2 | 2.28% | 4.55e-03 |
f[CL] | 1 | 2.03 | 2 | 1.27% | 2.54e-02 |
f[V1] | 20 | 47 | 50 | 6.06% | 3.03e+00 |
Compare Noise f[X]¶
Name | Initial | Fitted | True | Prop. Error | Abs. Error |
---|---|---|---|---|---|
f[PNOISE] | 0.1 | 0.139 | 0.15 | 7.41% | 1.11e-02 |
Compare Variance f[X]¶
Name | Initial | Fitted | True | Prop. Error | Abs. Error |
---|---|---|---|---|---|
f[KA_isv] | 0.05 | 0.137 | 0.1 | 37.43% | 3.74e-02 |
f[KA_isv;CL_isv] | 0.01 | 0.0157 | 0.02 | 21.29% | 4.26e-03 |
f[KA_isv;V1_isv] | 0.01 | 0.0621 | 0.01 | 521.48% | 5.21e-02 |
f[CL_isv;KA_isv] | 0.01 | 0.0157 | 0.02 | 21.29% | 4.26e-03 |
f[CL_isv] | 0.05 | 0.0392 | 0.03 | 30.50% | 9.15e-03 |
f[CL_isv;V1_isv] | 0.01 | 0.02… | 0.02 | 0.21% | 4.19e-05 |
f[V1_isv;KA_isv] | 0.01 | 0.0621 | 0.01 | 521.48% | 5.21e-02 |
f[V1_isv;CL_isv] | 0.01 | 0.02… | 0.02 | 0.21% | 4.19e-05 |
f[V1_isv] | 0.05 | 0.125 | 0.09 | 39.32% | 3.54e-02 |