Depot + One compartment PK with BLQ¶
[Generated automatically as a Tutorial summary]
Inputs¶
Description¶
Name: | blq_pk |
---|---|
Title: | Depot + One compartment PK with BLQ |
Author: | J.R. Hartley |
Abstract: |
Depot One Comp PK model, with BLQ (below level of quantification) observations.
Keywords: | tutorial; pk; advan4; dep_two_cmp; blq |
---|---|
Input Script: | blq_pk_tut.pyml |
Diagram: |
True f[X] values¶
f[KA] = 0.2000
f[CL] = 2.0000
f[V1] = 50.0000
f[KA_isv,CL_isv,V1_isv] = [
[ 0.1000, 0.0200, 0.0100 ],
[ 0.0200, 0.0300, 0.0200 ],
[ 0.0100, 0.0200, 0.0900 ],
]
f[PNOISE] = 0.1500
f[ANOISE] = 0.0100
Starting f[X] values¶
f[KA] = 1.0000
f[CL] = 1.0000
f[V1] = 20.0000
f[KA_isv,CL_isv,V1_isv] = [
[ 0.0500, 0.0100, 0.0100 ],
[ 0.0100, 0.0500, 0.0100 ],
[ 0.0100, 0.0100, 0.0500 ],
]
f[PNOISE] = 0.1000
f[ANOISE] = 0.0100
Outputs¶
Generating and Fitting Summaries¶
- Gen: Depot + One compartment PK with BLQ (gen)
- Fit: Depot + One compartment PK with BLQ (fit)
Fitted f[X] values¶
f[KA] = 0.1950
f[CL] = 2.0509
f[V1] = 48.4223
f[KA_isv,CL_isv,V1_isv] = [
[ 0.0137, 0.0118, -0.0107 ],
[ 0.0118, 0.0221, 0.0270 ],
[ -0.0107, 0.0270, 0.1372 ],
]
f[PNOISE] = 0.1486
f[ANOISE] = 0.0100
Plots¶
Comparison¶
True objective value¶
-725.8063
Final fitted objective value¶
-740.9643
Compare Main f[X]¶
Name | Initial | Fitted | True | Prop. Error | Abs. Error |
---|---|---|---|---|---|
f[KA] | 1 | 0.195 | 0.2 | 2.50% | 5.00e-03 |
f[CL] | 1 | 2.05 | 2 | 2.54% | 5.09e-02 |
f[V1] | 20 | 48.4 | 50 | 3.16% | 1.58e+00 |
Compare Noise f[X]¶
Name | Initial | Fitted | True | Prop. Error | Abs. Error |
---|---|---|---|---|---|
f[PNOISE] | 0.1 | 0.149 | 0.15 | 0.93% | 1.40e-03 |
Compare Variance f[X]¶
Name | Initial | Fitted | True | Prop. Error | Abs. Error |
---|---|---|---|---|---|
f[KA_isv] | 0.05 | 0.0137 | 0.1 | 86.29% | 8.63e-02 |
f[KA_isv;CL_isv] | 0.01 | 0.0118 | 0.02 | 40.98% | 8.20e-03 |
f[KA_isv;V1_isv] | 0.01 | -0.0107 | 0.01 | 207.29% | 2.07e-02 |
f[CL_isv;KA_isv] | 0.01 | 0.0118 | 0.02 | 40.98% | 8.20e-03 |
f[CL_isv] | 0.05 | 0.0221 | 0.03 | 26.29% | 7.89e-03 |
f[CL_isv;V1_isv] | 0.01 | 0.027 | 0.02 | 34.95% | 6.99e-03 |
f[V1_isv;KA_isv] | 0.01 | -0.0107 | 0.01 | 207.29% | 2.07e-02 |
f[V1_isv;CL_isv] | 0.01 | 0.027 | 0.02 | 34.95% | 6.99e-03 |
f[V1_isv] | 0.05 | 0.137 | 0.09 | 52.42% | 4.72e-02 |