Depot + One compartment PK with BLQ¶
[Generated automatically as a Tutorial summary]
Inputs¶
Description¶
Name: | blq_pk |
---|---|
Title: | Depot + One compartment PK with BLQ |
Author: | J.R. Hartley |
Abstract: |
Depot One Comp PK model, with BLQ (below level of quantification) observations.
Keywords: | tutorial; pk; advan4; dep_two_cmp; blq |
---|---|
Input Script: | blq_pk_tut.pyml |
Diagram: |
True f[X] values¶
f[KA] = 0.2000
f[CL] = 2.0000
f[V1] = 50.0000
f[KA_isv,CL_isv,V1_isv] = [
[ 0.1000, 0.0200, 0.0100 ],
[ 0.0200, 0.0300, 0.0200 ],
[ 0.0100, 0.0200, 0.0900 ],
]
f[PNOISE] = 0.1500
f[ANOISE] = 0.0100
Starting f[X] values¶
f[KA] = 1.0000
f[CL] = 1.0000
f[V1] = 20.0000
f[KA_isv,CL_isv,V1_isv] = [
[ 0.0500, 0.0100, 0.0100 ],
[ 0.0100, 0.0500, 0.0100 ],
[ 0.0100, 0.0100, 0.0500 ],
]
f[PNOISE] = 0.1000
f[ANOISE] = 0.0100
Outputs¶
Generating and Fitting Summaries¶
- Gen: Depot + One compartment PK with BLQ (gen)
- Fit: Depot + One compartment PK with BLQ (fit)
Fitted f[X] values¶
f[KA] = 0.2224
f[CL] = 1.9543
f[V1] = 51.0073
f[KA_isv,CL_isv,V1_isv] = [
[ 0.0697, 0.0196, 0.0527 ],
[ 0.0196, 0.0115, 0.0117 ],
[ 0.0527, 0.0117, 0.1872 ],
]
f[PNOISE] = 0.1473
f[ANOISE] = 0.0100
Plots¶
Comparison¶
True objective value¶
-725.9095
Final fitted objective value¶
-727.7713
Compare Main f[X]¶
Name | Initial | Fitted | True | Prop. Error | Abs. Error |
---|---|---|---|---|---|
f[KA] | 1 | 0.222 | 0.2 | 11.20% | 2.24e-02 |
f[CL] | 1 | 1.95 | 2 | 2.29% | 4.57e-02 |
f[V1] | 20 | 51 | 50 | 2.01% | 1.01e+00 |
Compare Noise f[X]¶
Name | Initial | Fitted | True | Prop. Error | Abs. Error |
---|---|---|---|---|---|
f[PNOISE] | 0.1 | 0.147 | 0.15 | 1.77% | 2.65e-03 |
Compare Variance f[X]¶
Name | Initial | Fitted | True | Prop. Error | Abs. Error |
---|---|---|---|---|---|
f[KA_isv] | 0.05 | 0.0697 | 0.1 | 30.27% | 3.03e-02 |
f[KA_isv;CL_isv] | 0.01 | 0.0196 | 0.02 | 2.16% | 4.32e-04 |
f[KA_isv;V1_isv] | 0.01 | 0.0527 | 0.01 | 427.44% | 4.27e-02 |
f[CL_isv;KA_isv] | 0.01 | 0.0196 | 0.02 | 2.16% | 4.32e-04 |
f[CL_isv] | 0.05 | 0.0115 | 0.03 | 61.61% | 1.85e-02 |
f[CL_isv;V1_isv] | 0.01 | 0.0117 | 0.02 | 41.42% | 8.28e-03 |
f[V1_isv;KA_isv] | 0.01 | 0.0527 | 0.01 | 427.44% | 4.27e-02 |
f[V1_isv;CL_isv] | 0.01 | 0.0117 | 0.02 | 41.42% | 8.28e-03 |
f[V1_isv] | 0.05 | 0.187 | 0.09 | 107.95% | 9.72e-02 |