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Depot + One compartment PK with BLQ

[Generated automatically as a Tutorial summary]

Inputs

Description

Name:blq_pk
Title:Depot + One compartment PK with BLQ
Author:J.R. Hartley
Abstract:
Depot One Comp PK model, with BLQ (below level of quantification) observations.
Keywords:tutorial; pk; advan4; dep_two_cmp; blq
Input Script:blq_pk_tut.pyml
Diagram:

Failed to create compartment diagram

True f[X] values

f[KA] = 0.2000
f[CL] = 2.0000
f[V1] = 50.0000
f[KA_isv,CL_isv,V1_isv] = [
    [ 0.1000, 0.0200, 0.0100 ],
    [ 0.0200, 0.0300, 0.0200 ],
    [ 0.0100, 0.0200, 0.0900 ],
]
f[PNOISE] = 0.1500
f[ANOISE] = 0.0100

Starting f[X] values

f[KA] = 1.0000
f[CL] = 1.0000
f[V1] = 20.0000
f[KA_isv,CL_isv,V1_isv] = [
    [ 0.0500, 0.0100, 0.0100 ],
    [ 0.0100, 0.0500, 0.0100 ],
    [ 0.0100, 0.0100, 0.0500 ],
]
f[PNOISE] = 0.1000
f[ANOISE] = 0.0100

Outputs

Generating and Fitting Summaries

Fitted f[X] values

f[KA] = 0.1957
f[CL] = 2.0245
f[V1] = 47.0079
f[KA_isv,CL_isv,V1_isv] = [
    [ 0.1365, 0.0159, 0.0617 ],
    [ 0.0159, 0.0390, 0.0200 ],
    [ 0.0617, 0.0200, 0.1256 ],
]
f[PNOISE] = 0.1389
f[ANOISE] = 0.0100

Plots

Dense comp plots

Alternatively see All dense_comp graph plots

Comparison

True objective value

-756.5645

Final fitted objective value

-763.9910

Compare Main f[X]

Name Initial Fitted True Prop. Error Abs. Error
f[KA] 1 0.196 0.2 2.15% 4.31e-03
f[CL] 1 2.02 2 1.23% 2.45e-02
f[V1] 20 47 50 5.98% 2.99e+00

Compare Noise f[X]

Name Initial Fitted True Prop. Error Abs. Error
f[PNOISE] 0.1 0.139 0.15 7.38% 1.11e-02

Compare Variance f[X]

Name Initial Fitted True Prop. Error Abs. Error
f[KA_isv] 0.05 0.136 0.1 36.46% 3.65e-02
f[KA_isv;CL_isv] 0.01 0.0159 0.02 20.28% 4.06e-03
f[KA_isv;V1_isv] 0.01 0.0617 0.01 516.52% 5.17e-02
f[CL_isv;KA_isv] 0.01 0.0159 0.02 20.28% 4.06e-03
f[CL_isv] 0.05 0.039 0.03 30.16% 9.05e-03
f[CL_isv;V1_isv] 0.01 0.02… 0.02 0.13% 2.59e-05
f[V1_isv;KA_isv] 0.01 0.0617 0.01 516.52% 5.17e-02
f[V1_isv;CL_isv] 0.01 0.02… 0.02 0.13% 2.59e-05
f[V1_isv] 0.05 0.126 0.09 39.55% 3.56e-02
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