One Compartment Model with Absorption and Inter-occasion Variance f[CL_isv]=0.5¶
[Generated automatically as a Tutorial summary]
Inputs¶
Description¶
| Name: | dep_one_cmp_cl_iov_05 |
|---|---|
| Title: | One Compartment Model with Absorption and Inter-occasion Variance f[CL_isv]=0.5 |
| Author: | Wright Dose Ltd |
| Abstract: |
Population one Compartment Model with Absorption and Inter-occasion Variance
Here f[CL_isv] true value is 0.5
| Keywords: | one compartment model; dep_one_cmp_cl; iov |
|---|---|
| Input Script: | dep_one_cmp_cl_iov_05.pyml |
| Diagram: |
True f[X] values¶
f[KA] = 0.3000
f[CL] = 3.0000
f[V] = 20.0000
f[PNOISE_STD] = 0.1000
f[ANOISE_STD] = 0.0500
f[CL_isv] = 0.5000
f[CL_iov] = 0.0100
Starting f[X] values¶
f[KA] = 0.5000
f[CL] = 1.0000
f[V] = 15.0000
f[PNOISE_STD] = 0.2000
f[ANOISE_STD] = 0.2000
f[CL_isv] = 0.0100
f[CL_iov] = 0.0100
Outputs¶
Generating and Fitting Summaries¶
Fitted f[X] values¶
f[KA] = 0.2686
f[CL] = 2.0908
f[V] = 18.1651
f[PNOISE_STD] = 0.0889
f[ANOISE_STD] = 0.0486
f[CL_isv] = 0.2834
f[CL_iov] = 0.0105
Plots¶
Comparison¶
True objective value¶
-352.8548
Final fitted objective value¶
-365.3289
Compare Main f[X]¶
| Name | Initial | Fitted | True | Prop. Error | Abs. Error |
|---|---|---|---|---|---|
| f[KA] | 0.5 | 0.269 | 0.3 | 10.46% | 3.14e-02 |
| f[CL] | 1 | 2.09 | 3 | 30.31% | 9.09e-01 |
| f[V] | 15 | 18.2 | 20 | 9.17% | 1.83e+00 |
Compare Noise f[X]¶
| Name | Initial | Fitted | True | Prop. Error | Abs. Error |
|---|---|---|---|---|---|
| f[PNOISE_STD] | 0.2 | 0.0889 | 0.1 | 11.06% | 1.11e-02 |
| f[ANOISE_STD] | 0.2 | 0.0486 | 0.05 | 2.79% | 1.40e-03 |
Compare Variance f[X]¶
| Name | Initial | Fitted | True | Prop. Error | Abs. Error |
|---|---|---|---|---|---|
| f[CL_isv] | 0.01 | 0.283 | 0.5 | 43.31% | 2.17e-01 |
| f[CL_iov] | 0.01 | 0.0105 | 0.01 | 5.18% | 5.18e-04 |